Table 1 Population characteristics at new baseline
Characteristics | MCI Reverters (N = 109) | Stable MCI (N = 334) | Stable NC (N = 353) | ap | bp |
|---|---|---|---|---|---|
1. Demographic information | |||||
Age, years, mean (SD) | 74.97 (6.48) | 77.30 (6.65) | 73.44 (6.63) | 0.002 | 0.034 |
Female, % | 66 (60.55%) | 211 (63.17) | 156 (44.19) | 0.623 | 0.003 |
Education, years, mean (SD) | 16.30 (2.68) | 15.66 (2.78) | 17.10 (2.22) | 0.032 | 0.007 |
APOE4 carrier, % | 33 (30.28%) | 137 (41.02%) | 106 (30.03%) | 0.045 | 0.961 |
2. Neuropsychological assessments | |||||
ADAS-cog, points | 9.29 (3.82) | 16.47 (6.53) | 6.88 (3.57)1 | < 0.001 | < 0.001 |
MEM, points | 0.78 (0.35) | 0.05 (0.47) | 1.17 (0.45) | < 0.001 | < 0.001 |
EXF, points | 0.75 (0.32) | 0.33 (0.51) | 1.01 (0.38) | < 0.001 | < 0.001 |
3. MRI characteristics | |||||
Hippocampus volume, cm³, mean (SD) | 7.29 (0.99)2 | 6.69 (1.04)3 | 7.46 (1.08)4 | < 0.001 | 0.183 |
Entorhinal volume, cm³, mean (SD) | 3.90 (0.74)5 | 3.56 (0.75)6 | 3.88 (0.63)7 | < 0.001 | 0.850 |
Mid-temporal volume, cm³, mean (SD) | 18.66 (6.08)5 | 17.48 (5.67)6 | 18.59 (6.28)7 | 0.142 | 0.927 |
4. PET characteristics | |||||
Amyloid PET, SUVr, mean (SD) | 1.13 (0.18)8 | 1.22 (0.24)9 | 1.11 (0.19)10 | 0.003 | 0.460 |
FDG-PET METAROI, SUVr, mean (SD) | 1.30 (0.10)8 | 1.20 (0.15)11 | 1.28 (0.12)11 | < 0.001 | 0.268 |
5. CSF biomarkers | |||||
CSF Aβ1-42, pg/ml, mean (SD) | 1146.90 (619.06)12 | 1061.80 (574.95)13 | 1376.60 (626.74)14 | 0.457 | 0.051 |
CSF p‐tau, pg/mL, mean (SD) | 25.48 (15.97)12 | 28.15 (14.73)13 | 22.05 (8.93)14 | 0.366 | 0.215 |
CSF t‐tau, pg/ml, mean (SD) | 267.80 (141.52)12 | 291.90 (125.35)13 | 245.20 (90.02)14 | 0.353 | 0.362 |
6. Aβ positive c, % | 29 (43.28%)15 | 109 (52.77%)16 | 77 (34.68%)17 | 0.071 | 0.171 |