Table 3 HRs (95% CIs) for combined macrovascular and microvascular events by HLFs score in key ADVANCE subgroups

Combined macrovascular and microvascular events

 Region of residence

0.329

  Asia

1.00

0.90 (0.71–1.14)

0.76 (0.60–0.97)

0.75 (0.55–1.02)

0.007

  Not Asia

1.00

0.81 (0.68–0.95)

0.69 (0.58–0.82)

0.65 (0.52–0.81)

 < 0.001

 Sex

0.301

  Men

1.00

0.84 (0.72–0.98)

0.69 (0.58–0.81)

0.67 (0.54–0.84)

 < 0.001

  Women

1.00

0.88 (0.67–1.14)

0.79 (0.60–1.03)

0.72 (0.51–1.00)

0.017

 Age, years

0.511

  < 65

1.00

0.90 (0.72–1.13)

0.71 (0.57–0.90)

0.79 (0.59–1.06)

0.004

  ≥ 65

1.00

0.81 (0.68–0.96)

0.72 (0.60–0.86)

0.62 (0.49–0.78)

 < 0.001

 Diabetes duration, years

0.828

  < 7

1.00

0.73 (0.59–0.90)

0.66 (0.53–0.81)

0.63(0.48–0.84)

 < 0.001

  ≥ 7

1.00

0.92 (0.77–1.10)

0.75 (0.62–0.90)

0.71 (0.56–0.90)

 < 0.001

 History of macrovascular disease

0.206

  No

1.00

0.88 (0.73–1.06)

0.79 (0.65–0.96)

0.72 (0.57–0.91)

0.001

  Yes

1.00

0.82 (0.67–1.00)

0.64 (0.52–0.79)

0.66 (0.49–0.88)

 < 0.001

 History of microvascular disease

0.919

  No

1.00

0.82 (0.70–0.95)

0.72 (0.62–0.84)

0.64 (0.53–0.79)

 < 0.001

  Yes

1.00

0.93 (0.69–1.26)

0.70 (0.51–0.95)

0.82 (0.54–1.24)

0.022