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Fig. 6 | BMC Medicine

Fig. 6

From: Cryoablation-induced modulation of Treg cells and the TGF-β pathway in lung adenocarcinoma: implications for increased antitumor immunity

Fig. 6

Cryoablation suppressed lung cancer metastasis in mouse models. A, B Masson staining results displayed redeposition of collagen in the Con group, forming thick, dense, straight collagen fibers passing through tumor nests; collagen fibers in the Cry group appeared loose and curved structures surrounding tumor nests. n = 3 mice per group. Statistical significance was evaluated using one-way ANOVA. *P < 0.05, Con vs. Cry + SB431542. C Assessment of metastatic lesions in mouse lungs revealed minimal metastases in the cryoablation group, with a comparison showing 60% versus 0% metastatic incidence between the control and cryoablation groups, respectively. n = 5 mice per group

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