Development and validation of the systemic nutrition/inflammation index for improving perioperative management of non-small cell lung cancer

Wang, Peiyu; Wang, Shaodong; Huang, Qi; Chen, Xiankai; Yu, Yongkui; Zhang, Ruixiang; Qiu, Mantang; Li, Yin; Pan, Xue; Li, Xiao; Li, Xiangnan

doi:10.1186/s12916-025-03925-2

Table 1 Predictive values of systemic nutrition/inflammation indicators for perioperative endpoints in the development cohort (n = 1497)

From: Development and validation of the systemic nutrition/inflammation index for improving perioperative management of non-small cell lung cancer

Parameters	Incidence of overall complications^a			Length of postoperative hospital stay^b
Parameters	AUC (95% CI)	P values	Associations	6 days	8 days	12 days	Associations
*The existing nutrition/inflammation indicators*
Biochemical groups
PNI	0.534 (0.490–0.579)	0.13	Negative	0.556	0.551	0.519	Negative
COUNT	0.565 (0.520–0.611)	0.004	Positive	0.547	0.569	0.556	Positive
AGR	0.546 (0.500–0.592)	0.044	Positive	0.558	0.527	0.543	Positive
NLR	0.565 (0.522–0.609)	0.004	Positive	0.557	0.562	0.556	Positive
PLR	0.523 (0.480–0.567)	0.31	Positive	0.506	0.54	0.509	Positive
NPR	0.557 (0.513–0.600)	0.013	Positive	0.558	0.539	0.541	Positive
LMR	0.600 (0.559–0.641)	< 0.001	Negative	0.579	0.582	0.564	Negative
SIRI	0.582 (0.539–0.625)	< 0.001	Positive	0.570	0.569	0.557	Positive
SII	0.532 (0.486–0.577)	0.17	Positive	0.528	0.542	0.530	Positive
Biochemical and anthropometry groups
GNRI	0.536 (0.490–0.582)	0.11	Negative	0.548	0.537	0.536	Negative
ALI	0.572 (0.528–0.615)	0.002	Negative	0.568	0.570	0.569	Negative
*The basic nutrition/inflammation items*
Total protein, g/L	0.535 (0.489–0.581)	0.13	Negative	0.579	0.537	0.530	Negative
Serum albumin, g/L	0.511 (0.466–0.556)	0.63	Negative	0.541	0.522	0.502	Negative
Serum globulin, g/L	0.551 (0.504–0.599)	0.024	Negative	0.579	0.538	0.545	Negative
Total cholesterol, mmol/L	0.569 (0.526–0.612)	0.002	Negative	0.590	0.587	0.587	Negative
Hemoglobin, g/L	0.526 (0.479–0.573)	0.26	Positive	0.528	0.525	0.524	Positive
Total neutrophils, × 10⁹/L	0.536 (0.489–0.583)	0.11	Positive	0.541	0.530	0.533	Positive
Total lymphocytes, × 10⁹/L	0.559 (0.514–0.603)	0.010	Negative	0.523	0.552	0.529	Negative
Total monocytes, × 10⁹/L	0.553 (0.510–0.596)	0.020	Positive	0.551	0.538	0.530	Positive
Total platelet, × 10⁹/L	0.546 (0.502–0.591)	0.042	Negative	0.528	0.525	0.524	Negative
*Newly proposed nutrition/inflammation indicator*
SNII	0.612 (0.571–0.653)	< 0.001	Negative	0.591	0.603	0.596	Negative

AGR albumin-to-globulin ratio, ALI advanced lung cancer inflammation index, CI confidence interval, CONUT controlling nutritional status score, GNRI geriatric nutritional risk index, LMR lymphocyte-to-monocyte ratio, NLR neutrophil-to-lymphocyte ratio, NPR neutrophil-to-platelet ratio, PLR platelet-to-lymphocyte ratio, PNI prognostic nutritional index, SII systemic immune-inflammation index, SIRI systemic inflammation response index, SNII systemic nutrition-inflammation index
^aReceiver operating characteristic (ROC) curves were utilized to evaluate the predictive values of nutrition/inflammation indicators for the incidence of postoperative complications
^bTime-dependent ROC curves were employed to assess the predictive value of nutrition/inflammation indicators concerning the length of postoperative hospital stay. Area under the curve (AUC) values are reported for these analyses. The specific time points analyzed were 6, 8, and 12 days post-surgery

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Table 1 Predictive values of systemic nutrition/inflammation indicators for perioperative endpoints in the development cohort (n = 1497)

BMC Medicine

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