Fig. 4

Plasma lipoproteins associated with liver steatosis and fibrosis and subclinical, prior, and incident cardiovascular disease. A Heatmap summarizing the results of the lipoproteomic analysis for PWH with liver steatosis and PWH with liver fibrosis, as well as PWH with CVD-related traits, including incident CVD, CVD history, and presence of plaque(s). Analyses were performed using linear regression models correcting for age, sex, ethnicities, and the use of cholesterol-lowering drugs. Additional correction for fat layer thickness was applied for MASLD. Asterisks indicate adjusted P values (FDR) < 0.05 (*), < 0.001 (**), and < 0.0001 (***). B Plasma metabolites alterations in PWH with simple steatosis compared to PWH with normal liver measurements specific for lean PWH (left column), overweight/obese PWH (middle column), or in both lean and overweight/obese PWH