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Table 2 Univariate and multivariate analysis of NST induced by blinatumomab

From: Adverse events in the nervous system associated with blinatumomab: a real-world study

 

Univariate

Multivariate

Variable

Waldχ2

P-value

β

S.E

Waldχ2

P-value

OR (95% CI)

Age

3.09 (t-test)

0.0020

0.00510

0.00175

8.5132

0.0035

1.01 (1.00—1.01)

Gender

0.87

0.3505

 − 0.0537

0.0781

0.4733

0.4915

0.95 (0.81–1.10)

Dermatological medications

31.54

 < .0001

0.1965

0.3053

0.4143

0.5198

1.22 (0.67–2.21)

Systemic corticosteroids, excluding sexual hormones and insulin

25.38

 < .0001

 − 0.0413

0.2181

0.0358

0.8498

0.96 (0.63–1.47)

Systemic anti-infective agents

26.21

 < .0001

 − 0.0581

0.1518

0.1466

0.7018

0.94 (0.70–1.27)

Antineoplastic and immunomodulating agents

3.36

0.0669

 − 0.1717

0.1091

2.4754

0.1156

0.84 (0.68–1.04)

Musculoskeletal system medications

5.07

0.0243

 − 0.4868

0.1842

6.9831

0.0082

0.61 (0.43–0.88)

Sensory organ system medications

29.38

 < .0001

 − 0.2119

0.2984

0.5040

0.4777

0.81 (0.45–1.45)

Antiparasitic, insecticidal, and anthelmintic drugs

14.59

0.0001

0.4944

0.3086

2.5674

0.1091

1.64 (0.90–3.00)

Digestive and metabolic system drugs

39.62

 < .0001

0.3641

0.2219

2.6917

0.1009

1.44 (0.93–2.22)

Genitourinary system and sexual hormones

31.14

 < .0001

0.3152

0.1431

4.8522

0.0276

1.37 (1.04–1.81)

Nervous system medication

58.39

 < .0001

0.6644

0.1544

18.5095

 < .0001

1.94 (1.44–2.63)

Cardiovascular system medications

30.83

 < .0001

0.0827

0.2154

0.1473

0.7011

1.09 (0.71–1.66)

Respiratory system medications

25.68

 < .0001

 − 0.1240

0.2189

0.3207

0.5712

0.88 (0.58–1.36)

Blood and hematopoietic organs medication

26.48

 < .0001

0.1530

0.1935

0.6251

0.4292

1.17 (0.80–1.70)

Other miscellaneous drugs

21.03

 < .0001

 − 0.1105

0.2043

0.2927

0.5885

0.90 (0.60–1.34)

  1. CI confidence interval, OR odds ratio, S.E standard error