From: Adverse events in the nervous system associated with blinatumomab: a real-world study
 | Univariate | Multivariate | |||||
---|---|---|---|---|---|---|---|
Variable | Waldχ2 | P-value | β | S.E | Waldχ2 | P-value | OR (95% CI) |
Age | 3.09 (t-test) | 0.0020 | 0.00510 | 0.00175 | 8.5132 | 0.0035 | 1.01 (1.00—1.01) |
Gender | 0.87 | 0.3505 |  − 0.0537 | 0.0781 | 0.4733 | 0.4915 | 0.95 (0.81–1.10) |
Dermatological medications | 31.54 |  < .0001 | 0.1965 | 0.3053 | 0.4143 | 0.5198 | 1.22 (0.67–2.21) |
Systemic corticosteroids, excluding sexual hormones and insulin | 25.38 |  < .0001 |  − 0.0413 | 0.2181 | 0.0358 | 0.8498 | 0.96 (0.63–1.47) |
Systemic anti-infective agents | 26.21 |  < .0001 |  − 0.0581 | 0.1518 | 0.1466 | 0.7018 | 0.94 (0.70–1.27) |
Antineoplastic and immunomodulating agents | 3.36 | 0.0669 |  − 0.1717 | 0.1091 | 2.4754 | 0.1156 | 0.84 (0.68–1.04) |
Musculoskeletal system medications | 5.07 | 0.0243 |  − 0.4868 | 0.1842 | 6.9831 | 0.0082 | 0.61 (0.43–0.88) |
Sensory organ system medications | 29.38 |  < .0001 |  − 0.2119 | 0.2984 | 0.5040 | 0.4777 | 0.81 (0.45–1.45) |
Antiparasitic, insecticidal, and anthelmintic drugs | 14.59 | 0.0001 | 0.4944 | 0.3086 | 2.5674 | 0.1091 | 1.64 (0.90–3.00) |
Digestive and metabolic system drugs | 39.62 |  < .0001 | 0.3641 | 0.2219 | 2.6917 | 0.1009 | 1.44 (0.93–2.22) |
Genitourinary system and sexual hormones | 31.14 |  < .0001 | 0.3152 | 0.1431 | 4.8522 | 0.0276 | 1.37 (1.04–1.81) |
Nervous system medication | 58.39 |  < .0001 | 0.6644 | 0.1544 | 18.5095 |  < .0001 | 1.94 (1.44–2.63) |
Cardiovascular system medications | 30.83 |  < .0001 | 0.0827 | 0.2154 | 0.1473 | 0.7011 | 1.09 (0.71–1.66) |
Respiratory system medications | 25.68 |  < .0001 |  − 0.1240 | 0.2189 | 0.3207 | 0.5712 | 0.88 (0.58–1.36) |
Blood and hematopoietic organs medication | 26.48 |  < .0001 | 0.1530 | 0.1935 | 0.6251 | 0.4292 | 1.17 (0.80–1.70) |
Other miscellaneous drugs | 21.03 |  < .0001 |  − 0.1105 | 0.2043 | 0.2927 | 0.5885 | 0.90 (0.60–1.34) |