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Table 1 Characteristics of the patients at baseline

From: Initial treatment with a single capsule containing half-dose quadruple therapy vs standard-dose dual therapy in hypertensive patients (QUADUAL): a randomized, blinded, crossover trial

 

Participants (N = 90)

 

Participants (N = 90)

Age (years)

43.88 (10.31)

TC (mmol/l)

5.22 (0.93)

Sex (Female)

23 (25.6%)

TG (mmol/l)

2.47 (1.96)

Race or ethnicity

 

LDL-C (mmol/l)

3.02 (0.86)

 Han

84 (93.3%)

HDL-C (mmol/l)

1.15 (0.28)

 Othersa

6 (6.7%)

HCY (umol/l)

12.45 [10.90, 14.80]

Time of HTN (months)

12 [2, 36]

Plasma renin (pg/ml)

13.61 [7.84, 22.39]

Ever treatedb

4 (4.4%)

Plasma aldosterone (pg/ml)

167.40 [138.26, 219.74]

Family history of HTN

73 (81.1%)

TSH (uIU/ml)

2.37 (1.51)

Family history of early onset cardiovascular disease

8 (8.9%)

Urinary protein

 

Smoking

26 (28.9%)

 -

70 (77.8%)

Alcohol

8 (8.9%)

 +

19 (21.1%)

Diabetes

4 (4.4%)

 +  +

1 (1.1%)

Coronary heart disease

0

Sinus rhythm

90 (100.0%)

Cerebrovascular disease

0

SV1 + RV5 (mv)

2.77 (0.78)

Peripheral vascular disease

0

QT (ms)

373.08 (29.96)

Sleep apneac

64 (71.1%)

QTc (ms)

419.24 (22.83)

BMI (kg/m2)

25.54 (3.02)

LA (mm)

31.57 (3.25)

Waistline (cm)

88.37 (8.92)

RA (mm)

30.16 (2.69)

Statin use

21 (23.3%)

LV (mm)

45.61 (3.63)

Fibrate use

5 (5.6%)

RV (mm)

28.40 (2.86)

Metformin use

4 (4.4%)

IVS (mm)

11.04 (1.23)

Serum potassium (mmol/l)

4.07 (0.36)

LVPW (mm)

10.62 (1.08)

Blood sodium(mmol/l)

143.14 (2.09)

LVEF (%)

68.79 (5.76)

FBG (mmol/l)

5.45 (1.26)

E/A

0.95 (0.33)

Glycosylated hemoglobin (%)

5.81 (1.18)

Carotid plaque

22 (24.4%)

Serum creatinine (umol/l)

73.42 (13.24)

IMT (mm)

0.87 (0.17)

Serum uric acid (umol/l)

378.22 (86.28)

ABI

1.17 (0.07)

Serum urea (mmol/l)

4.53 (1.23)

baPWV (cm/s)

1741.26 (273.94)

eGFR (ml/min/1.73m2)

103.12 (12.15)

ABPM character

 

ALT (U/L)

39.96 (29.90)

 Dippers

41 (45.6%)

AST (U/L)

28.20 (12.24)

 Non-dippers

47 (52.2%)

TBL (umol/l)

14.31 (5.29)

 Reverse-dippers

2 (2.2%)

DBL(umol/l)

4.08 (1.58)

  
  1. Data are mean (SD) (for normal distribution) or median [P25, P75] (for non-normal distribution) or number of patients (%)(for categorical variables)
  2. ABI Ankle brachial index, ABPM Ambulatory blood pressure monitoring, ALT Alanine transaminase, AST Aspartate transaminase, baPWV, Brachial-ankle pulse wave velocity, BMI Body mass index, DBL Direct bilirubin, E/A E/A ratio of mitral valve, eGFR Estimated glomerular filtration rate, FBG Fasting blood glucose, HCY Homocysteine, HDL-C High density lipoprotein cholesterol, HTN Hypertension, IMT carotid intima-media thickness, IVS Interventricular septum, LA Left atrium, LDL-C Low density lipoprotein cholesterol, LV Left ventricle, LVEF, Left ventricular ejection fraction, LVPW posterior wall of left ventricle, RA Right atrium, RV Right ventricle, TBL Total bilirubin, TC, Total cholesterol, TG Triglyceride, TIA Transient ischemic attack, TSH Thyroid stimulating hormone
  3. aChinese minority
  4. bEver taken blood pressure-lowering medications but not currently taking treatment for at least 1 month
  5. cMild sleep apnea which was not considered for the reason of hypertension