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Table 1 Demographic information of children delivered via cesarean section in Taiwan from 2015 to 2020

From: Association between general anesthesia for cesarean delivery and subsequent developmental disorders in children: a nationwide retrospective cohort study

 

GA, n (%)

NA, n (%)

P-valuea

Overall, n

6973

318,336

 

Maternal age at delivery (years)

 < 30

1797 (25.77)

84,525 (26.55)

 < 0.001

 30–34

2403 (34.46)

119,849 (37.65)

 

 35–39

2224 (31.89)

93,194 (29.28)

 

 ≥ 40

549 (7.87)

20,768 (6.52)

 

Socioeconomic deprivation

37 (0.53)

875 (0.27)

 < 0.001

Gestational status

 Coagulopathy or thrombocytopenia

187 (2.68)

1218 (0.38)

 < 0.001

 Hypertension or gestational hypertension

503 (7.21)

11,134 (3.50)

 < 0.001

 Preeclampsia or eclampsia

634 (9.09)

10,038 (3.15)

 < 0.001

 Diabetes mellitus or gestational diabetes mellitus

1057 (15.16)

23,521 (7.39)

 < 0.001

 Obesity

28 (0.40)

457 (0.14)

 < 0.001

 Fetal distress

651 (9.34)

5893 (1.85)

 < 0.001

 Congenital anomalies

349 (5.01)

3477 (1.09)

 < 0.001

 Premature rupture of membranes

624 (8.95)

11,946 (3.75)

 < 0.001

 Placenta previa

783 (11.23)

14,920 (4.69)

 < 0.001

 Placental abruption

456 (6.54)

3176 (1.00)

 < 0.001

 Antepartum hemorrhage

230 (3.30)

4290 (1.35)

 < 0.001

 Late pregnancy

513 (7.36)

11,006 (3.46)

 < 0.001

Delivery status

 Gestational age (weeks), median (Q1–Q3)

38 (36–39)

38 (37–39)

 < 0.001

 Preterm delivery (< 37 weeks)

1976 (28.34)

27,281 (8.57)

 < 0.001

 Birth weight (g), median (Q1-Q3)

2930 (2496–3260)

3065 (2810–3340)

 < 0.001

 Low birth weight (< 2,500 g)

1749 (25.08)

23,275 (7.31)

 < 0.001

 1-min Apgar score

8 (7–9)

8 (8–9)

 < 0.001

 < 7

1553 (22.27)

6598 (2.07)

 < 0.001

 ≧7

5420 (77.73)

311,738 (97.93)

 

 5-min Apgar score

8 (7–10)

8 (8–10)

 < 0.001

 < 7

1523 (21.84)

6496 (2.04)

 < 0.001

 ≧7

5450 (78.16)

311,840 (97.96)

 

Surgery duration (hours)

 < 2

6215 (89.13)

312,727 (98.24)

 < 0.001

 2–4

623 (8.93)

5508 (1.73)

 

 > 4

135 (1.94)

101 (0.03)

 

 NICU admission

884 (12.68)

5444 (1.71)

 < 0.001

Length of hospital stay of the infant (days)

 0

5551 (79.61)

306,789 (96.37)

 < 0.001

 1–6

471 (6.75)

5294 (1.66)

 

 ≧7

951 (13.64)

6253 (1.96)

 

Infant sex

 Male

3807 (54.60)

167,370 (52.58)

0.001

 Female

3166 (45.40)

150,966 (47.42)

 
  1. GA general anesthesia, NA neuraxial anesthesia, NICU neonatal intensive care unit
  2. aP-value was derived from Pearson’s chi-square test for categorical variables and Wilcoxon’s rank sum test for continuous variables